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For the proof of concept, a binary mixture of naproxen sodium (NAPR) and diphenhydramine hydrochloride (DIPH) marketed as Aleve pm ® tablets was selected ...

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Naproxen
Clinical data
Pronunciation/ n ə ˈ p r ɒ k s ən /
Trade namesAleve, Naprosyn, others [1]
AHFS/Drugs.comMonograph
MedlinePlusa681029
License dataUS  DailyMed:  43871
Pregnancy categoryAU: C US: C (Risk not ruled out)
Routes of administrationBy mouth
ATC codeG02CC02 ( WHO ) M01AE02 ( WHO ), M02AA12 ( WHO )
Legal status
Legal statusAU: S2 (Pharmacy only) when in preparations that contain no more than 15 days' supply. Otherwise it is Schedule 4 (Prescription only). [2] CA : OTC UK: POM (Prescription only) Pharmacy medicine (P) only for treatment of primary dysmenorrhoea in women aged 15–50 years subject to a maximum single dose of 500 mg, maximum daily dose of 750 mg for a maximum of 3 days, and max pack size of 9 × 250 mg tablets [3] US: OTC
Pharmacokinetic data
Bioavailability95% (by mouth)
Protein binding99%
MetabolismLiver (to 6-desmethylnaproxen)
Elimination half-life12–17 hours (adults) [4]
ExcretionKidney

OvDisordersPatient-Caregiver-EducationFact-SheetsLow-Back-Pain-Fact-Sheet. Ruled Angelina.

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